KKM Chemical Biology Lab
Organic Chemistry Section
Chemical Sciences and Technology Division
CSIR-National Institute for Interdisciplinary Science and Technology
Major Projects handled
On going Projects
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Development of Spectro-Cytology Screening Technology for Detection of Grades of Cervical Cancer Lesions by Surface Enhanced Raman Spectroscopy (SERS) and Artificial Intelligence; Principal Investigator- Dr. Kaustabh Kumar Maiti; Funding Agency: ICMR (Intermediary Grant), Rs. 3.96 Crore.
Duration: March, 2024 to March, 2028
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Design, Synthesis of Novel Naphthalene-Bipyridine appended Iridium (Nap-Ir) Photosensitizer for Targeted Nanoparticle Based Phototherapy in Breast Cancer Model; Principal Investigator- Dr. Kaustabh Kumar Maiti
Funding Agency: SERB-CRG, Rs. 46 Lakhs
Duration: March 2024 to March 2027
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Development of a sandwich model magnetic capture system for the detection of pancreatic cancer biomarkers in serum by SERS based immune assay; Principal Investigator : Dr.Vishnu Priya Murali & Project Mentor : Dr. Kaustabh Kumar Maiti
Funding Agency : DHR-ICMR ; 44.85 Lakhs ( 3 years)
Duration : November, 2021 - October, 2024
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Diagnostic Evaluation of a SERS-Nanoprobe Based Immunosensor for Early Detection of Alzheimer’s Disease Biomarkers from Blood
Funding Agency: ICMR ( 52 Lakhs for Ist Year)
Duration : March, 2022 to March 2025
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Technology for the early detection of cancer from blood sample using SERS (Surface Enhanced Raman Spectroscopy) and artificial intelligence- A novel technique
Funding Agency : CSR ( 74 Lakhs)
Duration : October 2022 to January 2024 (First phase)
Completed Projects
NON-CSIR Project
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Design A Smart Drug-Delivery System Using Activatable Cell- Penetrating Peptides and Scaffold Based Non-peptide Carriers For Targeting Human Cancer - Principal Investigator
Funding agency: DST (SERB) : 27 Lakhs
Duration : June 2013 - May, 2016
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Gold Nanorod Based Targeted Nanoprobe For Cancer Theranostics: Diagnosis By Surface Enhanced Raman Scattering (Sers) And Fluorescence Imaging And Therapy By PDT and PTT - Principal Investigator
Funding Agency: DBT; 84.224 Lakhs (3 years)
Duration : March 2016 - Feb 2019
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Development Of Multiplexing Detection Platform Of Breast Cancer Biomarkers By Non-Invasive Surface Enhanced Raman Scattering (Sers) Nanoprobe - Principal Investigator
Funding Agency: DST Nano Mission, 37.2 Lakhs (3 year);
Duration : August 2017 - Dec 2020
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Biocompatible Combined Polymer-Polysaccharide Core-shell VEGF-Targeted Nano-Carrier For Sustained Intraocular Pharmacotherapy Towards Diabetic Retinopathy - Principal Investigator
Funding Agency: DBT, 51.23 Lakhs (3 year)
Duration : September 2018 - August 2021
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Engineering intelligent theranostic nanocarrier for targeted therapy and diagnosis of cancer - Principal Investigator from NIIST
Funding Agency: DST, SERB, 16.6 Lakhs (3 year)
Duration : August 2018 - July 2021
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Nanostructured Surfaces for Developing SERS Sensing Platform - Co-Principal Investigator
Funding Agency: DBT 71.5 Lakhs (3 year)
Duration : September 2018 - August 2021
CSIR Network Projects: 12th FYP ( March, 2012 to March, 2017)
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Molecules To Materials To Devices (M2D)
Lab co-ordinator from CSIR-NIIST
Budget: 1933 Lakhs (NIIST)
Duration : March 2012 - March 2017
Major Achievement: Probes for SERS based detection of cervical cancer (CSIR-NIIST; TRL 4) - These nanoprobes are being validated in clinical samples through active collaboration with Regional Cancer Centre (RCC), Trivandrum (TLR 4)- Project Leader
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Nanomaterials: Application And Impact On Safety, Health And Environment (NanoSHE)
Nodal Scientist from CSIR-NIIST
Budget: 116 Lakhs
Major Achievement: Gold Nanorod based Theranostic Nanoprobe for Photothermal Chemotherapy to MMP2 expressed cancer tumors : (TRL3)- Nodal officer from NIIST
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Natural Products As Affordable Healthcare Agents (NaPaHa)
Participating Scientist from CSIR-NIIST
Budget: 500 Lakhs
Major Achievement: Isolation Of Anticancer Agent From Hydnocarpus Wightiana Blume. and Its Semi Synthetic Modifications For Enhanced Anticancer Activity – Participating Scientist from NIIST
CSIR Mission Mode Project
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Nanobiosensors and Microfluodics for Healthcare, Development of SERS-Nanoprobe for Multiplexing Diagnosis of Breast and Lung Cancer Biomarkers in Tumor Tissue Samples By Raman Fingerprint Duration : March 2018 - February 2020
Project Leader from NIIST / Budget: 749 Lakhs (For CSIR-NIIST)
CSIR FTT Project
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Development of Cellular Sensors: Biocompatible fluorescent molecules for sensing and cellular imaging of pH, Zn2+ and reactive oxygen species
Co-Principal Investigator / Budget : 75 Lakhs
Duration : Aug 2018 - March 2020
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Customized Portable Raman spectrophotometric device for multiplex detection of breast cancer biomarkers
Co-Principal Investigator / Budget : 132 Lakhs
Duration : June 2020 - March 2022
CSIR COVID-19 Project
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Development of Ultrasensitive, Rapid and Portable system for COVID-19 screening using Label-free Raman Fingerprinting and AI (MLP 0047)
Principal Investigator / Budget : 12 lakhs
Duration : June 2020 - Nov 2020
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Multiplexed lateral-flow device(s) for detection of COVID-19 (MLP0048)
(CSIR-NllST: COVID-19 Viral RNA detection kit with ultra-bright oligoprobes for the capture and detection of viral RNA via Lateral Flow based devices)